In agreement with these results, there was an apparent decreased expression of the CCR5 ligand chemokines CCL3 and CCL4 in the ileum and liver of CCR5-/- infected animals and of CCL5 in the ileum, when compared to WT infected mice, indicating that the reduced levels of inflammatory cytokines and transcription factors could be accompanied by a compromised accumulation of leukocytes, in both sites of infection (Figure 2C). This evidence concerns the gene CCL4 and infection.