CD8A and viral infectious disease: The anti-tumor effects of IT have been observed in a number of murine tumor models but whether this therapy would be effective against a tumor type completely devoid of NKG2D ligands remains unresolved.Further, in models of influenza infection, bystander CD8+ T cells (CD25−NKG2D+CD44high) also acutely expand and play an important role in controlling early viral infection in an antigen nonspecific manner [10].