In addition, we extended the analysis to patients with PACG and PEXG, as recent studies have suggested that common genetic factors might contribute to various forms of glaucoma [17].The aim of this study was to investigate the role of rs11720822 in PDIA5 and rs2754511 in BIRC6 in POAG, PACG and PEXG patients from the Pakistani population. The gene discussed is BIRC6; the disease is open-angle glaucoma.