Among several MMPs, MMP-2 and -9 have been demonstrated to be critical factors in tumor invasion (23), which is secreted by tumor cells as a pro-enzyme (pro-MMP-2) and activated in the extracellular milieu to execute their proteolytic activity, then accordingly enables cells to invade into the target organ and develop tumor metastasis (24,25). Here, MMP2 is linked to neoplasm.