Insulin resistance results when circulating levels of insulin are insufficient to regulate these process appropriately and it has been well documented that ageing is associated with a decline in insulin action (DeFronzo 1981; Rowe et al. 1983; Chen et al. 1988) which is thought to directly contribute to the high prevalence of IGT and type 2 diabetes with age (Enzi et al. 1986; Harris et al. 1987). This evidence concerns the gene INS and Insulin resistance.