Some evidence of apo composition of lipoprotein classes in MetSyn is available from the proteomic studies: thus, HDL (HDL3 subclass) isolated from dyslipidemic subjects (with new diagnosis of coronary artery disease) were reported to be enriched in apoE [18]; whereas LDL (small dense LDL subclass) from a different cohort of subjects with MetSyn were enriched in apoC3 and depleted of apoC1, apoA1, and apoE compared with matched healthy controls [19]. This evidence concerns the gene APOE and coronary artery disorder.