For example, hsa05200 (pathway in cancer) was regulated by 67 miRNAs (approximately 72% of the total miRNAs), while the four pathways with the highest degree of linkage [hsa05200 (pathway in cancer), hsa04722 (neurotrophin signaling pathway), hsa04010 (MAPK signaling pathway), hsa05215 (prostate cancer)] included about 99% (92 out of 93) of the total miRNAs, indicating that these four biological pathways were more likely to be regulated by the miRNAs. This evidence concerns the gene BDNF and prostate carcinoma.