However, hsa05200 (pathway in cancer) might not be the only pathway affected, since hsa05215 (prostate cancer) might also be influenced by miR-15a, miR-15b, miR-16, miR-497, miR-195 and their miRSNPs via affecting IGF1R, and hsa04722 (neurotrophin signaling pathway) might be likewise influenced by miR-181a, miR-181c, miR-143, miR-195 and their miRSNPs via KRAS and BCL2. Overall, IGF1R, IGF1, RAS, and BCL2 might be four high-risk genes in MG pathogenesis which could be regulated by many miRNAs and miRSNPs and influence several important MG risk pathways. This evidence concerns the gene IGF1R and Familial prostate cancer.