BDNF and Familial prostate cancer: For example, hsa05200 (pathway in cancer) was regulated by 67 miRNAs (approximately 72% of the total miRNAs), while the four pathways with the highest degree of linkage [hsa05200 (pathway in cancer), hsa04722 (neurotrophin signaling pathway), hsa04010 (MAPK signaling pathway), hsa05215 (prostate cancer)] included about 99% (92 out of 93) of the total miRNAs, indicating that these four biological pathways were more likely to be regulated by the miRNAs.