However, hsa05200 (pathway in cancer) might not be the only pathway affected, since hsa05215 (prostate cancer) might also be influenced by miR-15a, miR-15b, miR-16, miR-497, miR-195 and their miRSNPs via affecting IGF1R, and hsa04722 (neurotrophin signaling pathway) might be likewise influenced by miR-181a, miR-181c, miR-143, miR-195 and their miRSNPs via KRAS and BCL2. Overall, IGF1R, IGF1, RAS, and BCL2 might be four high-risk genes in MG pathogenesis which could be regulated by many miRNAs and miRSNPs and influence several important MG risk pathways. The gene discussed is IGF1; the disease is Familial prostate cancer.