The relative expression HSL mRNA was decreased (GDM median 0.53 AU (0.26–0.74) vs control 0.70 AU (0.43–1.27), P = 0.05) and that of Perilipin 1 increased (GDM median 0.40 AU (IQR 0.36–2.22) vs control 0.28 AU (0.18–0.67), P = 0.02) in placentae from women with GDM. This evidence concerns the gene PLIN1 and gestational diabetes.