Underscoring the importance of lipins in this latter process, mutation of mouse lipin-1 causes a near complete absence of TAGs in white adipose tissue and defects in adipocyte differentiation, both common signs of lipodystrophy, while overexpression of mouse lipin-1 promotes obesity [6], [7], [8]. This evidence concerns the gene LPIN1 and obesity due to melanocortin 4 receptor deficiency.