REST and epilepsy: Hippocampal NRSF expression increases several-fold following seizures (Palm et al., 1998; Garriga-Canut et al., 2006; McClelland et al., 2011a) and following other insults that promote epilepsy (Calderone et al., 2003; Noh et al., 2012; Kaneko et al., 2014).