Here, cytokine and chemokine production during HSV-2 infection showed size-related differences for each nanoparticle type - presence of 13 nm AgNPs at the time of infection led to production of CCL2, IFN-γ and IL-10, while 33 nm AgNPs induced CCL2, TNF-α and IL-10. The gene discussed is IFNG; the disease is infection.