CD4 and neoplasm: Although 5-fluorouracil and gemcitabine activate the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome complex within myeloid-derived suppressive cells and selectively eliminated them in tumor-bearing rodents, they also promote the release of IL-1β and the development of pro-angiogenic IL-17-producing CD4 T-cells, thus preventing a robust immune response against the tumor [44].