The contribution of PPARδ in hepatocyte proliferation and HCC is strongly discussed in the literature; PPARδ knock out animals are characterized by delayed LR exclusively in the early phases of LR, but no data are available for time points later than three days (when PPARδ KO liver weight/body weight ratio are comparable to wild type mice) [36]. The gene discussed is PPARD; the disease is hepatocellular carcinoma.