In detail, we identified the up-regulation of the pro-apoptotic caspase 8 (CASP8) [40], the tumor suppressors P67/methionyl aminopeptidase 2 (P67/MetAP2) [41], pyruvate dehydrogenase [lipoamide] kinase isozyme 4 (PDK4) [42] and protein angiopoietin-like 4 (ANGPTL4) [43] (which is suppressed in HCC when compared to perilesional tissue [44]), and of different genes known to be suppressed in HCC (i.e. CD82 [45]; WNT antagonist prickle homolog 1, PRICKLE1 [46]) and other neoplasms (i.e. DAZ associated protein 2, DAZAP2 [47]). This evidence concerns the gene PDK4 and hepatocellular carcinoma.