MOG and experimental autoimmune encephalomyelitis: All these data are consistent with in vivo findings in the experimental autoimmune encephalomyelitis model in which MOG (Myelin Oligodendrocyte Glycoprotein)-specific Th1 responses were severely compromised in Beclin 1-deficient mice (Beclin 1 was required for the initiation of autophagasome formation), whereas Th17 responses were only modestly affected[16].