The in vivo results mentioned above encouraged us to explore the possible molecular basis for celastrol’s action, so we observed its effects on pro-inflammatory molecules reportedly involved in DS, including cytokines TNFα and IL-1β, chemokines IL-8 and MCP-1, and the adhesive molecule ICAM-1 in NB4 induced by ATRA. This evidence concerns the gene ICAM1 and Dravet syndrome.