We hypothesize that there was a similar negative feedback in the progression of hepatic schistosomiasis, that is, NF-κB signaling in HSCs was activated at the early stage of infection and the expression of miR-146a/b up-regulated concurrently, subsequently targeting TRAF6 and, eventually, sequestering the NF-κB signaling. Here, NFKB1 is linked to infection.