Pathway analysis shows that the non-synonymous, splice-site, STOP and UTR SNPs most strongly differentiated between South Asians and Europeans (FST>0.10, P<10−13) identify genes involved in the structure and function of the skin and eyes (FLG, KRT3, HPS4, POU2F3, SLC45A2, TCHH, TYR, and TYRP1), in metabolism (AQP2, NEUROD1, PNPLA2, VDR and VLDLR), and in infection and immunity (including IFNGR1, ITGA4, ITGAE, ITGAL, SH2B3 and TLR6; Table S9 in File S2 and Table S10 in File S1, P<0.05). The gene discussed is HPS4; the disease is infection.