In blood, the animals show elevated levels of markers related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and oxidative stress (C-reactive protein, total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, blood pressure, ICAM-1 and PAI-1, insulin and oxidized LDL). The gene discussed is APOA1; the disease is endothelial dysfunction.