In order to determine the endogenous expression levels of Dicer1e in oral cancer cells, the expression of the ~93-kDa Dicer1e protein was examined in a panel of cell lines derived from tongue squamous cell carcinomas (SCCs) and compared to normal human oral keratinocytes (HOKs) by Western blot analysis (Figure 1A). This evidence concerns the gene DICER1 and lip and oral cavity carcinoma.