Stimulation of SCC-4 and SCC-25 cells with TGF-β, a known inducer of EMT in oral cancer cells [38, 39], was found to transition the cells from an epithelial to mesenchymal phenotype with a concurrent decrease in Dicer1e protein levels in comparison to unstimulated cells (Figure 1C). This evidence concerns the gene DICER1 and lip and oral cavity carcinoma.