EHMT2 and cancer: Subsequent studies have reported epigenetic activation of the serine-glycine biosynthetic pathway by G9a upon serine depletion in cancer cells[12] and have shown that G9a and H3K9 methylations were required to sustain cancer cell behaviors like hypoxia response, cell proliferation, metabolism, autophagy, cancer stemness, and epithelial-mesenchymal transition[12, 14–17].