Second, in the subgroup analysis may have had insufficient statistical power to check an association, Third, we were also unable to examine the interactions among gene-environment, lacking of the original data of the included studies limited our further evaluation of potential interactions, which may be an important component of the association between CYP1A2*F, CYP1B1 Leu432Val, Asn453Ser, and Arg48Gly polymorphisms and environment and colorectal cancer risk. The gene discussed is CYP1B1; the disease is colorectal cancer.