Overall, no significant association was found between CYP1B1 Leu432Val polymorphism and colorectal cancer susceptibility (dominant model: OR = 1.00, 95% CI = 0.94–1.06, Ph = 0.770, I2 = 0.0%; recessive model: OR = 1.05, 95% CI = 0.98–1.13, Ph = 0.251, I2 = 20.3%; homozygote model: OR = 1.04, 95% CI = 0.96–1.13, Ph = 0.383, I2 = 6.3%; heterozygote model: OR = 0.98, 95% CI = 0.91–1.04, Ph = 0.687, I2 = 0.0%; additive model: OR = 1.02, 95% CI = 0.98–1.06, Ph = 0.498, I2 = 0.0%). This evidence concerns the gene CYP1B1 and colorectal cancer.