Overall, no significant association was found between CYP1B1 Arg48Gly polymorphism and colorectal cancer susceptibility (dominant model: OR = 0.99, 95% CI = 0.91–1.08, Ph = 0.780, I2 = 0.0%; recessive model: OR = 1.00, 95% CI = 0.86–1.16, Ph = 0.138, I2 = 40.1%; homozygote model: OR = 1.00, 95% CI = 0.86–1.16, Ph = 0.124, I2 = 42.1%; heterozygote model: OR = 0.99, 95% CI = 0.91–1.08, Ph = 0.989, I2 = 0.0%; additive model: OR = 0.97, 95% CI = 0.91–1.03, Ph = 0.135, I2 = 38.6%). The gene discussed is CYP1B1; the disease is colorectal cancer.