AKT1 and familial pancreatic carcinoma: This can be related to the crucial role of AKT in the pathologic process of a number of common human malignancies [30],[31], including breast cancer, prostate cancer, lung cancer, gastrointestinal tumors, pancreatic cancer, hepatocellular carcinoma, thyroid cancer, and CNS malignancies (such as glioblastoma and gliomas), and other disorders such as schizophrenia [29].