Given that PFKFB3 and PFKFB4 are co-expressed in several cancer cell lines and have the redundant function of synthesizing F2,6BP, we postulate that selective inhibition of a single family member may result in compensation by a co-expressed PFKFB family member, and that combinations of PFKFB3 and PFKFB4 inhibitors may be necessary in order to fully suppress tumor glucose metabolism and growth. The gene discussed is PFKFB3; the disease is cancer.