PFKFB4 and lung adenocarcinoma: A PFKFB4 siRNA was found to reduce F2,6BP and glycolytic flux to lactate in A549 lung adenocarcinoma cells (U.S. Patent #8,283,332) and two other PFKFB4 siRNAs were independently observed to reduce lactate secretion and the intracellular ATP in malignant glioma cells [14].