EZH2 mediated transcriptional repression of putative tumor suppressors such as E-cadherin [43] via increased H3K27me3 is dependent on SET domain that in addition to methyl transferase activity also requires histone de-acetylase activity, possibly through recruitment of HDAC2 by EZH2, itself a component of PRC2 complex [44]. The gene discussed is HDAC2; the disease is neoplasm.