ID4 and Familial prostate cancer: In contrast, ID4 promoter was highly enriched for the RNA polymerase II and H3 acetylation (0.55+0.078 and 0.70+0.144, P<0.001, respectively) in benign prostate as compared to prostate cancer (0.12+0.061 and 0.35+0.051, respectively) (Fig. 3B).