MTOR and cancer: The paradox between this model and our data might arise, to a large extent, from cellular genetic backgrounds and microenvironments: mTOR activity is hyperactivated by deregulated upstream factors in numerous cancer types, to adapt hypermetabolic demands and nutrient deficiency stresses [49]; however, mTOR dependent circuitry of metabolic toxicity occurred under excessive nutrient conditions [48], a feature shared by diabetes and other ageing-related pathologies.