Ectopic Aur-A overexpression exacerbated γH2AX signals accumulation in both SKBR-3 and BT-549 cells (Fig. 3D & Supplementary Fig. S4), suggesting that by suppressing autophagic cell death, Aur-A might promote tumor progression under metabolic stress in breast cancer cells. This evidence concerns the gene AURKA and breast carcinoma.