The results of the present study can be summarized as follows: i) miR-182 is significantly up-regulated during colon carcinogenesis, and is associated to CRC patients prognosis; ii) miR-182 exerts a suppressive regulation on ENTPD5, suggesting novel molecular pathways in colon carcinogenesis; iii) miR-182 up-regulation can be detected in CRC plasma samples, and is therefore eligible as a novel diagnostic and non-invasive follow-up marker. This evidence concerns the gene ENTPD5 and colorectal carcinoma.