MiR-124 in turn is regulated by transcriptional repressor Enhancer of Zeste Homolog 2 (Drosophila) EZH2 and transcriptional co-repressor C-terminal binding protein 1 (CtBP1), genes that are overexpressed in aggressive prostate cancer [7, 16]. This evidence concerns the gene EZH2 and Familial prostate cancer.