P4HA1 and prostate adenocarcinoma: We conducted Oncomine Platform (Life Technologies, Ann Arbor, MI) database analyses on publicly available microarray datasets and found that P4HA1 is over-expressed in prostate adenocarcinoma (Supplementary Fig. S1A; p=8.57E-4) and metastatic samples (Supplementary Fig. S1B; p=2.22E-7) compared with normal tissues [20, 21].