Therefore, we detected the expression of cyclinD1 and other cell cycle regulator CyclinD2,CyclinD3,CyclinE1 and P21 in the GC cells transfected with FBXO31 expression vector or FBXO31 siRNA and found that FBXO31 overexpression suppressed, whereas its inhibition increased, the expression of CyclinD1,respectively. The gene discussed is CCND1; the disease is gastric cancer.