Furthermore, we found that 4EGI-1 selectively inhibits translation of mRNAs encoding proteins that are enhanced in CSC maintenance, proliferation and metastasis, such as NANOG, OCT4, c-MYC, cyclin D1, CXCR4, VEGF and c-MYB, in breast CSC tumor cells. Here, POU5F1 is linked to neoplasm.