POU5F1 and neoplasm: 4EGI-1 treated tumor cells presented decreased CSC pluripotency markers NANOG and OCT4, tumor metastasis regulator CXCR4, EMT mediator c-MYB and proangiogenic factor VEGF[40, 41], but not translation initiation factors eIF1A or eIF5, comparing to vehicle treated breast CSC tumor cells in vivo (Fig. 5A).