CDT2 was suppressed in twelve cancer cell lines from different human tumor tissues and shown to be transformed and tumorigenic, and six non-transformed human cell lines, among which four commercially available cell lines (HK2, hTERT-HME-1, MCF 10A and MRC-5) and two primary cultures of human cells, i.e. Human Umbilical Vein Endothelial Cells (HUVEC) [34] and human osteoblasts (HOB) obtained from cultures of bone-derived cells [35]. Here, DTL is linked to cancer.