1)Breast cancer: Suppression of nerve growth factor Trk receptors and prolactin receptors Prostate cancer: NF-κB/cyclin D and cyclin E, Suppression of nerve growth factor Trk receptors and prolactin receptors.2)Glioma: Inhibition Ca(2+) influx3)Bone cancer: Attenuates mechanical hyperalgesia. This evidence concerns the gene PRLR and breast carcinoma.