PI3 and Familial prostate cancer: 1)Breast cancer: (block G2 - M phase transition)- Activates the transcription factor JunD Anti-tumor action in MMTV-neu mice via inhibition of AKTAnti-invasive effect-modulate MMP-2/MMP-9 pathway2)Prostate cancer:PI-3/AKT and Raf-1/ERK1/2 pathwayMitogenic effect at low doses.3)Lung cancer: ERK1/2, JNK and AKT pathwayMitogenic effect at low doses.4)Glioma: MMP-2pathway, ER stress mediated autophagy5)Lymphoma: MAPK/ERK pathway