RB1 and Familial prostate cancer: 1)Breast cancer: Regulates COX-2/PGE2 signaling pathway2)Prostate cancer: Sustained activation of ERK1/23)Skin cancer: Inhibits pro-angiogenic growth factor, AKT and pRB pathway4)Glioma: Ceramide and NF-Κb pathway5)Lymphoma: Ceramide and p38 pathway