MMP2 and central nervous system cancer: 1)Breast cancer: mitogenic effect in cells expressing low levels of CB1/CB2 receptors.2)Prostate cancer: PI3K/Akt and Raf-1/ERK1/2 pathway Mitogenic at low doses3)Lung cancer: EGFR/ERK1/2, c-Jun-NH2-kinase1/2, and Akt pathway. Mitogenic at low doses4)Glioma: MMP-2 pathway