1)Breast cancer: ER stress/ERK and reactive oxygen species (ROS) pathways2)Prostate cancer: ERK1/2 and AKT pathways3)Lung cancer: up-regulation of TIMP-1 Cox-2 and PPAR-γ regulation4)Cervical cancer: Up-regulation of TIMP1. This evidence concerns the gene TIMP1 and Familial prostate cancer.