In this paper, we report the development, validation and technique translation (RT-PCR) of a 5-gene classifier (including risk genes ULBP2, SLC7A2, PDLIM3, AMIGO2, and the protective gene CCL11) derived from a 108-gene expression signature obtained from a microarray of deregulated genes in CAFs from colorectal cancer (Molecular Oncology 10.1016/j.molonc.2014.04.006). The gene discussed is SLC7A2; the disease is colorectal cancer.