FGFR2 and non-small cell lung carcinoma: Mark et al. have demonstrated various levels of expression of the FGF family proteins, FGFR1 and FGFR2, in NSCLC cell lines, and also shown that FGF2/FGFR1 autocrine signaling affects their sensitivities to gefitinib and FGFR-TKI (36).