Mark et al. have demonstrated various levels of expression of the FGF family proteins, FGFR1 and FGFR2, in NSCLC cell lines, and also shown that FGF2/FGFR1 autocrine signaling affects their sensitivities to gefitinib and FGFR-TKI (36). The gene discussed is FGF2; the disease is non-small cell lung carcinoma.