PIDD1 and cancer: These conditions may have been subject to stress-induced aberrant gene expression, such as cancer susceptibility CASC4, or genes related to p53 which is induced by DNA damage or stress stimuli such as PIDD, and USP4. Yet, the proteins encoded by these genes were found to be expressed in human OCs, and their splicing profiles were significantly modified in OCs from PBD patients compared to controls.