Taken together, the present results reveal a surprisingly limited role for ASC and NLRP3 during in vivo S. Typhimurium infection when dissecting different local and systemic compartments, especially given the fact that Salmonella infection is generally believed to be intracellular and that the inflammasome has previously been described to be crucial for the host defense against other intracellular pathogens [9]. The gene discussed is PYCARD; the disease is Salmonella Infections.