We found no difference when comparing WT, Asc−/− and Nlrp3−/− mice in our colitis model with respect to bacterial counts and dissemination towards the liver and the systemic compartment 4 days after infection (Figure 5B-D), which corresponds to our findings in the typhoid model; the only exception being a slight increase in bacterial counts in the MLNs of Asc−/− mice when compared to MLNs from WT mice. The gene discussed is PYCARD; the disease is infection.