Phospho-mTOR, pp70S6K, pPDK1, PI3K, pPTEN, and PTEN levels were further reduced in cancer cells cotreated with Sal and MK-2206, when compared to cancer cells treated with either MK-2206 or Sal alone (Figures 4(a) and 4(b)). The gene discussed is MTOR; the disease is cancer.