Regarding the IHC profile of SSL found in colon, the loss of hMLH-1 and MGMT was reported to play an important role in the serrated neoplasia carcinogenesis pathway [16], and colon carcinomas with high-level microsatellite instability (MSI) have been estimated to be in at least 20% of the right-sided colon carcinomas. The gene discussed is MLH1; the disease is colon carcinoma.