Compared with the ischemia group, the expression levels of SIRT1 had significant difference compared with normal group, sham-operated group, XFZY group, and Res group, while the expression levels of P53, (NF)-kappa B, FOXO1, FOXO3, and FOXO4 were significantly different with ischemia group and L-NAME group. Here, FOXO4 is linked to ischemia.