INSR and polycystic ovary syndrome: Among the SNPs in exon 17 of INSR detected to date the C/T SNP at His1058 in the tyrosine kinase domain containing the ATP binding site of INSR has been shown to be associated with the development of PCOS most possibly by the resultant effects on the auto phosphorylation of the INSR function in some women with PCOS (6, 9, 10).