In contrast, MyD88−/−TRIF−/− mice were similar to their MyD88−/− counterparts, with reduced H. polygyrus adult worm survival (Fig. 5C) and egg production (Fig. 5D), compared with wild-type mice, by day 28 post infection, confirming that MyD88 is a key adapter protein in host susceptibility to H. polygyrus. Here, MYD88 is linked to infection.