NR3C1 and post-traumatic stress disorder: Although a number of studies have also shown that GR polymorphisms are associated with changes in GCs sensitivity or altered cortisol [24,26,27], few studies have indicated that PTSD is associated with the presence of single nucleotide polymorphisms (SNPs) in genes associated with GR. Individuals with PTSD after intensive care therapy who carried the homozygous G-allele of the BclI SNP (rs41423247) had more severe PTSD than non-carriers or heterozygous carriers [28].