For these reasons the 3 cell types, Caco-2 cells (from a human colon adenocarcinoma) with a p53 non-functional gene (∆p53: mut p53) and Neuro-2A (from a mouse neuroblastoma cells), and HepG2 cells (from a human hepatocellular carcinoma) with functional p53 genes were selected. Here, TP53 is linked to colon adenocarcinoma.