The IFN-induced expression of these ISGs in Huh7 hepatoma cells was verified by quantitative real time PCR as being strongly IFN-induced (>10-fold) and the ISGs were placed into the following categories: 1) ISGs whose expression is predominantly driven by an ISRE; 2) ISGs whose expression is predominantly driven by an ISRE and potentially regulated by NF-κB; 3) ISGs whose expression is predominantly driven by an SIE; and 4) ISGs whose expression is predominantly driven by an SIE, and potentially regulated by NF-κB. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.