We conducted a cross-sectional population-based study in the Klang Valley region, Malaysia to assess the distribution of PSA level across different age as well as ethnic groups and determine the association between age, ethnicity, family history of prostate cancer, height, weight, lower urinary tract voiding symptoms (LUTS), DRE and prostate volume on elevated PSA levels. This evidence concerns the gene KLK3 and Familial prostate cancer.