HLA-C and neoplasm: As opposed to antigen-recognition by conventional αβ T cells, γδ T cell-specific antigens do not need to be processed by professional antigen-presenting cells, do not require binding presentation by classical major histocompatibility complex (MHC) molecules and are therefore able to exert potent MHC-unrestricted cytotoxic effector activity toward various tumour cells including GBM [27], [28].