In the 1,030 Get With The Guidelines (GWTG) – Stroke hospitals including 71,169 acute ischemic stroke patients treated with IV-tPA, the proportion of patients with DTN ≤60 min improved from 26.5% during the preintervention period of 2003–2009 to 41.3% during the postintervention period of 2010–2013 by the Target: Stroke strategies for quality improvement [30]. Here, PLAT is linked to stroke disorder.