The advantages of administering IV-tPA in the stroke intensive care unit included a standardized intensive care unit medical bed for precise body weight measurement, rapid access to IV-tPA stored in the intensive care unit, sufficient numbers of skilled nurses familiar with IV-tPA bolus and infusion protocols, close monitoring and management of blood pressure, and availability of bedside carotid duplex and transcranial color-coded sonography to assist in diagnosis of such conditions as large artery occlusion or dissection. Here, PLAT is linked to Stroke.