DnaJA3 knockout mice develop dilated cardiomyopathy [40], a mutation in DnaJB6 cause autosomal dominant myopathy [41] and mutations in DnaJC5 and 9 cause or are associated with autosomal-dominant adult-onset neuronal ceroid lipofuscinosis and schizophrenia with deficits in attention, respectively [42], [43], while DnaJC29 (also known as sacsin) is mutated in autosomal recessive spastic ataxia of Charlevoix-Saguenay [44]. This evidence concerns the gene SACS and autosomal recessive spastic ataxia.