To further test any possible associations between Lefty and CHD, we conducted SNP analyses and found that the rs2295418 (g.C925A) variant in Lefty2 gene was obviously associated with the risk of CHD; the genotype frequency of the rs360057 (g.A1035C) variant in Lefty1 gene was associated with the risk of CHD, but there was no statistical significance in the allele frequency. Here, LEFTY1 is linked to coronary artery disorder.