ChIP experiments show that the Sp1 occupies its binding sites in the promoters of XIAP, CRABP1, MDK, and KCNMA1 (Fig. 5), and that DIG-MSK decreases Sp1 binding to them with a superior effect on KCNMA1, a gene associated with high proliferation in cancer cells [40]. Here, SIK1 is linked to cancer.