EGFR and non-small cell lung carcinoma: EGFR members are abnormally activated by several mechanisms like receptor over-expression, mutation, ligand-dependent receptor dimerization, ligand-independent stimulation, and are associated with the development of tumors of epithelial origin, including non-small cell lung cancer (NSCLC) [30], breast [31], colorectal [32], and pancreatic cancer [33].